synthesis, labeling, formulation and quality control of 99mtc-tricine-hynic-tyr³-octreotide, a peptide radiopharmaceutical for imaging somatostatin receptor positive tumors [persian]

نویسندگان

mostafa gandomkar

reza najafi

seyed esmail sadatebrahimi

abbas shafiee

mohammad hossein babaei

چکیده

somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. in this study tyr³-octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-boc-hydrazinopyridine-3-carboxylic acid (boc-hynic) and after deprotecting of conjugate, purification was performed with preparative-rp-hplc. the conjugated peptide was labeled with 99mtc and tricine as coligand. radiolabelling efficiency, radiochemical purity, stability in human serum, internalization of receptor bound 99mtc-labeled peptide and biodistribution in normal mice were studied.

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Synthesis, labeling, formulation and quality control of 99mTc-Tricine-HYNIC-Tyr³-Octreotide, a peptide radiopharmaceutical for imaging Somatostatin receptor positive tumors [Persian]

Somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. In this study Tyr³-Octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-BOC-hydrazinopyridine-3-carboxylic acid (BOC-HYNIC) and after deprotecting of conjugate, purification was performed wit...

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عنوان ژورنال:
iranian journal of nuclear medicine

ناشر: tehran university of medical sciences

ISSN 1681-2824

دوره 11

شماره 1 2003

کلمات کلیدی

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